A platform of diverse human-based hepatic in vitro models & technologies for therapeutic and diagnostic applications
HepaSCREEN takes a tiered approach to the development of a range of industry relevant models and tools for liver toxicity, disease prediction and therapeutic applications. The platform comprises a diverse range of human-based (stem) cell models, ranging from simple (2D, high-throughput compatible…) to more complex hepatic cell systems (3D, co-cultures, fluidic…), tailored to DILI, NAFLD, NASH and diagnostic applications.
HepaSCREEN models
We look for partners who require adaptable in vitro models and tools towards industry needs.
Funding & Projects
![](/swfiles/files/640x240_B-Liver_FWO.png?nc=1600424663)
iPSCs in DILI & NAFLD
iPSC-based parenchymal and sinusoidal liver cell for DILI and NAFLD studies (iPSC-LiMic)
led by Leo van Grunsven
LIPOSTEM
In vitro model based on human skin-derived stem cells to study de novo lipogenesis in the liver
led by Tamara Vanhaecke
iPSCs & FIBROSIS
A novel pooled functional genomics strategy in inducible pluripotent stem cells for the identification of therapeutic targets for liver fibrosis
led by Leo van Grunsven
![](/swfiles/files/640x240_B-Liver_Horizon2020.png?nc=1600424733)
TWINALT
Twinning towards excellence in alternative methods for toxicity assessment
led by Tamara Vanhaecke
![](/swfiles/files/640x320_B-Liver_MarieC.png?nc=1600424744)
ChOLLATERAL
Generation of an adverse outcome pathway network on cholestatic liver injury for mechanism-based in vitro testing of chemicals
led by Mathieu Vinken